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General Test Procedure (GTP) for Description

PURPOSE
To lay down the procedure for the description of materials.

APPARATUS
  • Clean and dry Petri dish or watch glass
  • Clean and dry 50 ml Nessler’s cylinder.

REAGENTS
Not applicable.

PROCEDURE

For Solids:
  • Spread evenly about 1 to 2 g of the solid sample in a Petri dish or in a watch glass. Observe the following in diffuse daylight against a white background.
  • The nature of the substance [powder, crystalline etc.,]
  • The colour of the substance.
  • Any extraneous matter present.
  • Any lumps or non-homogeneity.
  • In the case of tablets observe for shape, colour, score and embossment, if any.
  • In the case of capsules observe for capsule size, the colour of the capsule shell and the colour of the filled material.


For Liquids:
  • Transfer 10 to 25 ml of the liquid to a dry Nessler’s cylinder. Observe the following in diffuse daylight against a white background.
  • Colour of the liquid.
  • Clarity of the liquid.
  • Any characteristic odour perceived during handling.
  • Settlement of any extraneous matter on standing.
  • In the case of oral solutions observe for clarity, the colour of the solution and also for sedimentation, if any.
  • In case of oral suspensions observe for colour and sedimentation, if any.

REFERENCES
USP
BP

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