HOT POST

50/recent/ticker-posts

Header Ads Widget

General Test Procedure for Miscellaneous Solvents

PURPOSE
To lay down the procedure for testing of miscellaneous solvents

INSTRUMENTATION & APPARATUS
Not applicable

REAGENTS
Not applicable

PROCEDURE

Description
  • Visually observed the solvents and note down the observation in the record.
Solubility
  • Refer pharmacopeia for respective solvents and it shall be tested.
Identification
  • The retention time of the major peak in the chromatogram of the sample corresponds to that of the standard obtained as directed in the purity test.
  • Place the bottle in the drying chamber (oven or desiccators) as directed in the individual test procedure, remove the stopper and leave it also in the chamber.
  • Dry the sample to constant weight or for a specified time and at the temperature indicated in the individual test procedure.
  • Constant weight: Two consecutive weights should not differ not more than 0.50 mg.
  • After drying is completed, open the drying chamber, close the bottle promptly and allow it to cool to room temperature in desiccators before weighing.
  • Weigh the bottle and contents.
Calculation
Empty LOD bottle weight: W1
LOD bottle + sample weight: W2
After drying LOD bottle + sample weight: W3


REFERENCES
British Pharmacopeia

Post a Comment

0 Comments

close