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Troubleshooting Problems Detected by Smell, Sight or Sound in HPLC

You need to use all your senses to identify LC problems. You should get in the habit of taking a few minutes each day to expose all of your senses (except taste!) to the LC so that you can get a “feel” for how the LC performs normally.

This will help you to quickly locate problems. For example, often you can smell a leak before you see it. The majority of problems are identified by sight; most of these are included in the preceding section.

Solvent Smell

“Hot” Smell

Abnormal Meter Readings

Warning Lamps

Warning Buzzers

Squeaks and Squeals

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