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SOP for Calibration of Burettes

OBJECTIVE
To lay down a procedure for Calibration of Burettes

SCOPE
This procedure applies to the pharmaceutical manufacturing facilities of XYZ Limited.

RESPONSIBILITY
The Quality Control Chemist is responsible for implementation of the process.
The Quality Control Manager is responsible for the execution of the procedure.


PROCEDURE
  • Fill a clean burette, previously tested for leakage to the zero mark with distilled water at 20°C or 25°C.
  • A definite volume, e.g. 10ml is allowed to run into a tare bottle and the weight of water with-drawn is determined.
  • The burette is filled again to zero
  • Repeat the procedure and divide the weights by 0.99718 if water at 20°C is used or by 0.99602 if water at 25°C is used to get the actual volume.
  • All the calibration details shall be entered in the calibration log for Burettes.

REFERENCE(s)
Nil.

ABBREVIATION(s)
SOP : Standard Operating Procedure
Q.A Quality Assurance
No. Number
Q.C Quality control
°C Degree centigrade

ANNEXURE(s)
Annexure No. – 1 - Calibration log for burettes

 
REVISION CARD
Nil

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