SOP for Operation of Dissolution Apparatus

To lay down the Operation procedure of dissolution test apparatus for better and error-free use. 

This procedure is applicable for all dissolution test apparatus apparatus installed in Quality Control Laboratory.

Execution : Chemist and above – QC department. 
Checking : Asst. Manager and above – QC department 

  • Ensure that working bench and instrument is clean. 
  • Ensure that the instrument is calibrated. 
  • Switch on the mains power. 
  • Fill the bath with water up to the mark leveled. 
  • Switch on the instrument. 
  • When the power is on, the display shows previously set time, RPM and the temperature display shows the bath temperature. 
  • Place the lift jar filled with the medium according to the STP. 
  • Fix the paddle/basket according to the product STP. 
  • Press the temperature set switch and rotate the setting knob till digital display shows 37°C. 
  • Change the mode switch to RPM mode and switch on the motor. 
  • Using speed knob, adjust the RPM to required level and switch off the motor.
  • Press both Alarm and Reset switch so that Timer display shows 0.00. 
  • By pressing both Alarm and Slow or Alarm and Fast, set Alarm to the required time 
  • Allow the bath temperature instrument. 
  • After the test is completed the instrument will stop which is indicated by beep sound. 
  • Press the ↑ and ↓ keys to lift the stirrer unit. 
  • Take the required amount of the sample from the jars and clean. 
  • Switch OFF the instrument.

SOP - Standard Operating Procedure 
Q.A - Quality Assurance 
Q.C - Quality control 
USP - United States Pharmacopoeia 


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