SOP for Handling of Chemicals and Reagents

To lay down a procedure for handling of reagents and chemicals in quality control department. 

This procedure is applicable for all chemicals and reagents, received in Quality Control Department. 

Execution: Chemist and above – QC department. 
Checking: Asst. Manager and above – QC department 

  • On the receipt of Reagent and Chemicals, inspect the each container for its integrity and expiry date, if mentioned on the labels; otherwise assign a self-life for a period of 5 years. Label each container with Date of Receipt, Expiry and maintain the status. 

Date of Receipt:  ……………………………

Expiry              :  ………………………………

Date of Opening: ……………………………

Use  before    :  ………………………………

  • Store the material as recommended by manufacturer if not recommended, store in laboratory at ambient condition. 
  • Issue the intact container of material as per requirement. 
  • Maintain the status of Reagents and Chemicals in the Laboratory as per the Annexure-1 
  • At the time of opening mention the Date of opening and use before on the label 
  • Use the open material container within 2 years after the date of opening for solid material and one year for liquid material or before expiry date mentioned by manufacture, whichever is earlier. 
  • During use if any physical discrepancies or contamination observed in any Reagent and Chemical discontinue the use of that Reagent and Chemical. 
  • After expiry chemical shall be diluted with water by taking full precaution, wear protective wear such as hand gloves, safety goggles, nose mask etc. and finally decant the water in soak pit area.

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Hazardous Chemical: 
  • Hazardous material is a material which is capable of producing harmful physical and health effects. 
  • Harmful physical effects include fire, sudden release of pressure, explosion and other violent reactions. 
  • The chemicals which are labeled as per following category & symbol are considered to be Hazardous. 
Harmful health effects includes acute and chronic condition. 

Liquids: Any Liquid having flash point below 100°F. 
Solids: Substance that can cause fire through friction, absorption of moisture or spontaneous chemical changes, when ignited will burn vigorously. 

Substances which give rise to highly exothermic reaction in contact with other substances, particularly flammable substances.  

Substance which destroy living tissues. 

Substances so toxic that it presents risk to life or health. 

Chemical compound or mixtures that react, decompose with release of gas and heat. 

Dangerous to environment: 
Substances which, were they to enter into the environment would present or might present and immediate pr delayed danger for one or more components of the environment. 

Handling of Hazardous chemicals: 
  • While handling hazardous chemicals the QC personal should wear protective wear such as hand gloves, safety goggles, nose mask etc. 
  • Keep yourself away from container while pouring out the chemicals. Use suction bulb for pipetting the chemicals. 
  • While preparing dilute acid solutions take special care as follows. First cool the aqueous solution in ice bath. Slowly add acid into the solution with constant stirring.
  • Keep inflammable liquids and substances away from naked flame or electric spark. 
  • Avoid breathing of vapors of spilled material. 

SOP - Standard Operating Procedure 
Q.C - Quality control 

Annexure-1 - Issuance record of reagent and chemicals
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